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Showing results for crystal and millar
Search for Crystal-Ann Millar instead (1 results)
Towards Better Delivery of Cannabidiol (CBD).
Millar SA, Maguire RF, Yates AS, O'Sullivan SE. Millar SA, et al. Pharmaceuticals (Basel). 2020 Aug 28;13(9):219. doi: 10.3390/ph13090219. Pharmaceuticals (Basel). 2020. PMID: 32872355 Free PMC article. Review.
Potential avenues to overcome these issues with CBD include self-emulsifying drug delivery systems, improved crystal formulations and other solid-state delivery formulations, which are mostly in the pre-clinical or early clinical stages of development. ...
Potential avenues to overcome these issues with CBD include self-emulsifying drug delivery systems, improved crystal formulations and …
The year in G protein-coupled receptor research.
Millar RP, Newton CL. Millar RP, et al. Mol Endocrinol. 2010 Jan;24(1):261-74. doi: 10.1210/me.2009-0473. Epub 2009 Dec 17. Mol Endocrinol. 2010. PMID: 20019124 Free PMC article. Review.
These insights will guide us in our understanding of how GPCRs operate, both in the normal and pathological situation. Although these crystal structures are highly informative, it is important to recognize that they represent static frozen conformations of a single GPCR st …
These insights will guide us in our understanding of how GPCRs operate, both in the normal and pathological situation. Although these cry …
Biocatalytic control of site-selectivity and chain length-selectivity in radical amino acid halogenases.
Kissman EN, Neugebauer ME, Sumida KH, Swenson CV, Sambold NA, Marchand JA, Millar DC, Chang MCY. Kissman EN, et al. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2214512120. doi: 10.1073/pnas.2214512120. Epub 2023 Mar 13. Proc Natl Acad Sci U S A. 2023. PMID: 36913566 Free PMC article.
In this context, we elucidate the basis for the selectivity of enzymes that perform selective halogenation to yield 4-Cl-lysine (BesD), 5-Cl-lysine (HalB), and 4-Cl-ornithine (HalD), allowing us to probe how site-selectivity and chain length selectivity are achieved. We now repor …
In this context, we elucidate the basis for the selectivity of enzymes that perform selective halogenation to yield 4-Cl-lysine (BesD), 5-Cl …
Dapagliflozin and Liraglutide Therapies Rapidly Enhanced Bone Material Properties and Matrix Biomechanics at Bone Formation Site in a Type 2 Diabetic Mouse Model.
Mieczkowska A, Millar P, Chappard D, Gault VA, Mabilleau G. Mieczkowska A, et al. Calcif Tissue Int. 2020 Sep;107(3):281-293. doi: 10.1007/s00223-020-00720-4. Epub 2020 Jul 8. Calcif Tissue Int. 2020. PMID: 32642787
At the tissue level, significant alterations in phosphate/amide ratio, carbonate/phosphate ratio, tissue water content, crystal size index, collagen maturity and collagen glycation were observed and linked to alteration of matrix biomechanics. ...At bone formation site, da …
At the tissue level, significant alterations in phosphate/amide ratio, carbonate/phosphate ratio, tissue water content, crystal size …
Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells.
Benveniste PM, Roy S, Nakatsugawa M, Chen ELY, Nguyen L, Millar DG, Ohashi PS, Hirano N, Adams EJ, Zúñiga-Pflücker JC. Benveniste PM, et al. Sci Immunol. 2018 Dec 14;3(30):eaav4036. doi: 10.1126/sciimmunol.aav4036. Sci Immunol. 2018. PMID: 30552102
Cloning and transferring of MART-1-specific gammadelta TCRs restored the specific recognition of the initial antigen MHC/peptide reactivity and conferred antigen-specific functional responses. A crystal structure of a MART-1-specific gammadelta TCR, together with MHC/pepti …
Cloning and transferring of MART-1-specific gammadelta TCRs restored the specific recognition of the initial antigen MHC/peptide reactivity …
Preintervention Profiles of Information, Motivational, and Behavioral Self-Efficacy for Methamphetamine Use and HIV Medication Adherence Among Gay and Bisexual Men.
Starks TJ, Millar BM, Lassiter JM, Parsons JT. Starks TJ, et al. AIDS Patient Care STDS. 2017 Feb;31(2):78-86. doi: 10.1089/apc.2016.0196. Epub 2017 Jan 16. AIDS Patient Care STDS. 2017. PMID: 28092450 Free PMC article.
Although rates of crystal methamphetamine use in the United States have fallen from their peak in the mid-2000s, use remains a major public health concern, which disproportionately affects gay and bisexual men (GBM). ...Although the information, motivation, and behavioral …
Although rates of crystal methamphetamine use in the United States have fallen from their peak in the mid-2000s, use remains a major …
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.
Soares DC, Bradshaw NJ, Zou J, Kennaway CK, Hamilton RS, Chen ZA, Wear MA, Blackburn EA, Bramham J, Böttcher B, Millar JK, Barlow PN, Walkinshaw MD, Rappsilber J, Porteous DJ. Soares DC, et al. J Biol Chem. 2012 Sep 21;287(39):32381-93. doi: 10.1074/jbc.M112.393439. Epub 2012 Jul 27. J Biol Chem. 2012. PMID: 22843697 Free PMC article.
We determined that full-length NDE1 forms needle-like dimers and tetramers in solution, similar to crystal structures of NDEL1, as well as chain-like end-to-end polymers. ...
We determined that full-length NDE1 forms needle-like dimers and tetramers in solution, similar to crystal structures of NDEL1, as we …
The iron-sulfur cluster assembly (ISC) protein Iba57 executes a tetrahydrofolate-independent function in mitochondrial [4Fe-4S] protein maturation.
Mühlenhoff U, Weiler BD, Nadler F, Millar R, Kothe I, Freibert SA, Altegoer F, Bange G, Lill R. Mühlenhoff U, et al. J Biol Chem. 2022 Oct;298(10):102465. doi: 10.1016/j.jbc.2022.102465. Epub 2022 Sep 6. J Biol Chem. 2022. PMID: 36075292 Free PMC article.
To test this idea for mitochondrial Iba57, we performed genetic and biochemical studies in Saccharomyces cerevisiae, and we solved the crystal structure of Iba57 from the thermophilic fungus Chaetomium thermophilum. ...
To test this idea for mitochondrial Iba57, we performed genetic and biochemical studies in Saccharomyces cerevisiae, and we solved the cr …
Afterload-induced left ventricular diastolic dysfunction during myocardial ischaemia and reperfusion.
Diakos NA, Pozios I, Katsaros L, Vakrou S, Sventzouri S, Michelinakis N, Tseliou E, Bonios M, Malliaras K, Papalois A, Anastasiou-Nana M, Terrovitis JV. Diakos NA, et al. Exp Physiol. 2015 Mar;100(3):288-301. doi: 10.1113/expphysiol.2014.082131. Epub 2015 Feb 2. Exp Physiol. 2015. PMID: 25523362 Free article.
We examined the following factors: (i) the consequences of increasing the LV afterload on LV diastolic function during acute ischaemia and reperfusion; (ii) whether the myocardial response to afterload elevation is stable throughout a 2 h reperfusion period; and (iii) the role of …
We examined the following factors: (i) the consequences of increasing the LV afterload on LV diastolic function during acute ischaemia and r …
A rapid change in magma plumbing taps porphyry copper deposit-forming magmas.
Carter LC, Tapster SR, Williamson BJ, Buret Y, Selby D, Rollinson GK, Millar I, Parvaz DB. Carter LC, et al. Sci Rep. 2022 Oct 14;12(1):17272. doi: 10.1038/s41598-022-20158-y. Sci Rep. 2022. PMID: 36241642 Free PMC article.
We attribute this change to a shift from extraction of quartz monzodiorite and quartz monzonite magmas evolving in mid-crustal reservoirs, and that had relatively poor ore-forming potential, to extraction of volatile-rich granitic magmas from greater (~ 30 km) depths. As the gran …
We attribute this change to a shift from extraction of quartz monzodiorite and quartz monzonite magmas evolving in mid-crustal reservoirs, a …
61 results